The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer

Abstract Background Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) earlier, this clinical aim still remains a significant challenge. Aberrant methylation patterns of linked CpGs analyzed in DNA fragments shed by cancers into the bloodstream (i.e. cell-free DNA...

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Hlavní autoři: Martin Widschwendter, Michal Zikan, Benjamin Wahl, Harri Lempiäinen, Tobias Paprotka, Iona Evans, Allison Jones, Shohreh Ghazali, Daniel Reisel, Johannes Eichner, Tamas Rujan, Zhen Yang, Andrew E. Teschendorff, Andy Ryan, David Cibula, Usha Menon, Timo Wittenberger
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2017-12-01
Edice:Genome Medicine
Témata:
Cell-free DNA
DNA methylation
Serum DNA
Ovarian cancer
Early diagnosis
Screening
On-line přístup:http://link.springer.com/article/10.1186/s13073-017-0500-7
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