Localization-associated immune phenotypes of clonally expanded tumor-infiltrating T cells and distribution of their target antigens in rectal cancer

The degree and type of T cell infiltration influence rectal cancer prognosis regardless of classical tumor staging. We asked whether clonal expansion and tumor infiltration are restricted to selected-phenotype T cells; which clones are accessible in peripheral blood; and what the spatial distributio...

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Main Authors: Livius Penter, Kerstin Dietze, Julia Ritter, Maria Fernanda Lammoglia Cobo, Josefin Garmshausen, Felix Aigner, Lars Bullinger, Holger Hackstein, Sandra Wienzek-Lischka, Thomas Blankenstein, Michael Hummel, Klaus Dornmair, Leo Hansmann
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis Group 2019-06-01
Serija:OncoImmunology
Teme:
rectal cancer
tumor-infiltrating lymphocytes
single cell technologies
t cell receptor sequencing
single cell immune phenotyping
clonal t cell expansion
t cell antigen specificity
human immunology
cancer immunology
Online dostop:http://dx.doi.org/10.1080/2162402X.2019.1586409
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