G Protein-Coupled Receptor 109A and Host Microbiota Modulate Intestinal Epithelial Integrity During Sepsis

The intestinal epithelial barrier is important to mucosal immunity, although how it is maintained after damage is unclear. Here, we show that G protein-coupled receptor 109A (GPR109A) supports barrier integrity and decreases mortality in a mouse cecum ligation and puncture (CLP) sepsis model. Data f...

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Detalhes bibliográficos
Main Authors: Guangxin Chen, Bingxu Huang, Shoupeng Fu, Bai Li, Xin Ran, Dewei He, Liqiang Jiang, Yuhang Li, Bingdong Liu, Liwei Xie, Juxiong Liu, Wei Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-09-01
Colecção:Frontiers in Immunology
Assuntos:
GPR109A
gut microbiota
intestinal epithelial barrier
CLP
sepsis
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.02079/full
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