Improving selectivity and productivity of the enzymatic synthesis of ampicillin with immobilized penicillin G acylase

An experimental design was applied to improve the reaction conditions for enzymatic synthesis of ampicillin from phenylglycine methyl ester (PGME) and 6-aminopenicillanic acid (6-APA), catalyzed by penicillin G acylase from E. coli immobilized on an agarose-glyoxyl derivative. The presence and magni...

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Main Authors: A. L. O. Ferreira, R. L. C. Giordano, R. C. Giordano
Formato: Artigo
Idioma:Inglês
Publicado em: Brazilian Society of Chemical Engineering 2004-12-01
Colecção:Brazilian Journal of Chemical Engineering
Assuntos:
Ampicillin
immobilized enzyme
beta -lactam antibiotic synthesis
factorial design
Acesso em linha:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322004000400002
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