Differential proteomic analysis of fetal and geriatric lumbar nucleus pulposus: immunoinflammation and age-related intervertebral disc degeneration

Abstract Background Intervertebral disc degeneration (IVDD) is a major cause of low back pain. Although the mechanism of degeneration remains unclear, aging has been recognized as a key risk factor for IVDD. Most studies seeking to identify IVDD-associated molecular alterations in the context of hum...

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Hlavní autoři: Chensheng Qiu, Xiaolin Wu, Jiang Bian, Xuexiao Ma, Guoqing Zhang, Zhu Guo, Yan Wang, Yandong Ci, Qizun Wang, Hongfei Xiang, Bohua Chen
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2020-06-01
Edice:BMC Musculoskeletal Disorders
Témata:
Intervertebral disc degeneration
Proteomics
Tandem mass tag
Aging
Inflammatory response
On-line přístup:http://link.springer.com/article/10.1186/s12891-020-03329-8
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