Role of Rutin in 5-Fluorouracil-Induced Intestinal Mucositis: Prevention of Histological Damage and Reduction of Inflammation and Oxidative Stress

Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU). Rutin (RUT), a natural flavonoid extracted from <i>Dimorphandra gardneriana</i>, exhibit...

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Main Authors: Lázaro de Sousa Fideles, João Antônio Leal de Miranda, Conceição da Silva Martins, Maria Lucianny Lima Barbosa, Helder Bindá Pimenta, Paulo Vitor de Souza Pimentel, Claudio Silva Teixeira, Marina Alves Sampaio Scafuri, Samuel de Osterno Façanha, João Erivan Façanha Barreto, Poliana Moreira de Medeiros Carvalho, Ariel Gustavo Scafuri, Joabe Lima Araújo, Jefferson Almeida Rocha, Icaro Gusmão Pinto Vieira, Nágila Maria Pontes Silva Ricardo, Matheus da Silva Campelo, Maria Elenir Nobre Pinho Ribeiro, Gerly Anne de Castro Brito, Gilberto Santos Cerqueira
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2020-06-01
Serija:Molecules
Teme:
flavonoid
inflammation
antimetabolites
intestine
Online dostop:https://www.mdpi.com/1420-3049/25/12/2786
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