Restriction of the Global IgM Repertoire in Antiphospholipid Syndrome

The typical anti-phospholipid antibodies (APLA) in the anti-phospholipid syndrome (APS) are reactive with the phospholipid-binding protein β2GPI as well as a growing list of other protein targets. The relation of APLA to natural antibodies and the fuzzy set of autoantigens involved provoked us to st...

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Bibliographic Details
Main Authors: Shina Pashova, Lubomir Balabanski, Gabriel Elmadjian, Alexey Savov, Elena Stoyanova, Velizar Shivarov, Peter Petrov, Anastas Pashov
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
IgM
antibody repertoire
antiphospholipid syndrome
Igome
deep panning
sequence graphs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.865232/full
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