The first experience in using abiraterone acetate in patients with castration-refractory prostate cancer

Even in the mid-twentieth century, Huggins and Hodges proved the susceptibility of prostate cancer cells to hormonal manipulations, by using surgical castration as an example. An average of 18–36 months after initiation of first-line hormonal therapy, patients develop the castration resistance in pr...

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Bibliographic Details
Main Authors: L. M. Rapoport, E. A. Bezrukov, A. V. Kondrashina
Format: Artigo
Language:Russo
Published: ABV-press 2015-11-01
Series:Andrologiâ i Genitalʹnaâ Hirurgiâ
Subjects:
castration-refractory prostate cancer
intracrine synthesis of testosterone
hypersusceptibility of tumor receptors
hyperproduction of tumor receptors
dehydroepiandrosterone
postcastration testosterone level
cytochrome p45017α
inhibitor cyp17
second-line hormonal therapy
abiraterone acetate
Online Access:https://agx.abvpress.ru/jour/article/view/154
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