Exosomal MiR-199a-5p Inhibits Tumorigenesis and Angiogenesis by Targeting VEGFA in Osteosarcoma

BackgroundOsteosarcoma (OS) is the most common primary bone malignancy in children and adolescents. microRNAs have been found to play a vital role in tumor angiogenesis. Here, we investigated the effects of miR-199a-5p on tumor growth and angiogenesis in osteosarcoma. Furthermore, the underlying mol...

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Detalhes bibliográficos
Main Authors: Lu Zhang, Hongxin Cao, Guanghui Gu, Dehui Hou, Yunhao You, Xiang Li, Yunzhen Chen, Guangjun Jiao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Oncology
Assuntos:
osteosarcoma
exosome
angiogenesis
miR-199a-5p
VEGFA
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2022.884559/full
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