Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits

Abstract Background Age-related macular degeneration (AMD) is a common condition of vision loss with disease development strongly influenced by environmental and genetic factors. Recently, 34 loci were associated with AMD at genome-wide significance. So far, little is known about a genetic overlap b...

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Hauptverfasser: Felix Grassmann, Christina Kiel, Martina E. Zimmermann, Mathias Gorski, Veronika Grassmann, Klaus Stark, International AMD Genomics Consortium (IAMDGC), Iris M. Heid, Bernhard H. F. Weber
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2017-03-01
Schriftenreihe:Genome Medicine
Schlagworte:
Age-related macular degeneration
AMD
Genetic risk scores
GRS
Genetic association studies
Complex traits
Online Zugang:http://link.springer.com/article/10.1186/s13073-017-0418-0
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