RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer

The influence of mRNA splicing on colon cancer development and progression is unclear. In this study, the authors demonstrate that the SRSF1 splicing factor is essential to sustain the stem cell phenotype of WNT-activated colorectal cancers.

Сохранить в:
Библиографические подробности
Главные авторы: Adam E. Hall, Sebastian Öther-Gee Pohl, Patrizia Cammareri, Stuart Aitken, Nicholas T. Younger, Michela Raponi, Caroline V. Billard, Alfonso Bolado Carrancio, Aslihan Bastem, Paz Freile, Fiona Haward, Ian R. Adams, Javier F. Caceres, Paula Preyzner, Alex von Kriegsheim, Malcolm G. Dunlop, Farhat V. Din, Kevin B. Myant
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Portfolio 2022-05-01
Серии:Nature Communications
Online-ссылка:https://doi.org/10.1038/s41467-022-30489-z
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы