Identification of IL-6 Signalling Components as Predictors of Severity and Outcome in COVID-19

IL-6 is one of the major mediators of the hyper-inflammatory responses with complex biological functions as it can signal via different modes of action. IL-6 by classical signalling has anti-inflammatory and antibacterial activities, while trans-signalling mediates pro-inflammatory effects. The net...

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Main Authors: María Ángeles Rodríguez-Hernández, David Carneros, María Núñez-Núñez, Ramón Coca, Rosario Baena, Gema M. López-Ruiz, María Elena Cano-Serrano, Alberto Martínez-Tellería, Ana Fuentes-López, Juan Manuel Praena-Fernandez, Christoph Garbers, José Hernández-Quero, Federico García, Stefan Rose-John, Matilde Bustos
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
COVID-19
IL-6
soluble receptors
soluble IL-6 receptor (sIL-6R)
soluble gp130 (sgp130)
IL-6 trans-signalling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.891456/full
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