The Bradykinin System Contributes to the Regulation of Prostaglandin-Endoperoxide Synthase 2 Expression in Human Amnion Fibroblasts: Implications for Term and Preterm Birth

BackgroundBradykinin (BK) and its biologically active metabolite des-Arg9 bradykinin (DABK) play a pivotal role in inflammation. Since chorioamnionitis is the leading cause of preterm birth and prostaglandin E2 (PGE2) derived from the amnion is key to labor initiation, we investigated if bradykinin...

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Autori principali: Xiao-tian Ni, Wang-sheng Wang, Yun Liu, Yi-kai Lin, Fan Zhang, Wen-jia Lei, Li-jun Ling, Fan Pan, Ya-nan Zhu, Meng-die Li, Tao Duan, Ming Liu, Kang Sun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-05-01
Serie:Frontiers in Endocrinology
Soggetti:
bradykinin
cyclooxygenase-2
PGE2
fetal membranes
preterm birth
parturition
Accesso online:https://www.frontiersin.org/articles/10.3389/fendo.2022.873727/full
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