Deriving stratified effects from joint models investigating gene-environment interactions

Abstract Background Models including an interaction term and performing a joint test of SNP and/or interaction effect are often used to discover Gene-Environment (GxE) interactions. When the environmental exposure is a binary variable, analyses from exposure-stratified models which consist of estima...

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Detalhes bibliográficos
Main Authors: Vincent Laville, Timothy Majarian, Paul S. de Vries, Amy R. Bentley, Mary F. Feitosa, Yun J. Sung, D. C. Rao, Alisa Manning, Hugues Aschard, on behalf of the CHARGE Gene-Lifestyle Interactions Working Group
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-06-01
Colecção:BMC Bioinformatics
Assuntos:
Gene-environment interaction
Binary exposure
Stratified analysis
Summary statistics
Acesso em linha:http://link.springer.com/article/10.1186/s12859-020-03569-4
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