Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators

Multidrug resistance (MDR) in cancer is one of the main limitations for chemotherapy success. Numerous mechanisms are behind the MDR phenomenon wherein the overexpression of the ATP-binding cassette (ABC) transporter proteins P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidr...

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Main Authors: Bruno M. F. Gonçalves, David S. P. Cardoso, Maria-José U. Ferreira
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-07-01
Colecção:Molecules
Assuntos:
cancer
multidrug resistance
natural products
ABC-transporters
nitrogen-containing flavonoid derivatives
nitrogen-containing terpenoid derivatives
Acesso em linha:https://www.mdpi.com/1420-3049/25/15/3364
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