Evaluation of human primary intestinal monolayers for drug metabolizing capabilities

Abstract Background The intestinal epithelium is a major site of drug metabolism in the human body, possessing enterocytes that house brush border enzymes and phase I and II drug metabolizing enzymes (DMEs). The enterocytes are supported by a porous extracellular matrix (ECM) that enables proper cel...

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Detalhes bibliográficos
Main Authors: Jennifer E. Speer, Yuli Wang, John K. Fallon, Philip C. Smith, Nancy L. Allbritton
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-11-01
Colecção:Journal of Biological Engineering
Assuntos:
Drug metabolism
CYP3A4
Stiffness
Extracellular matrix
Small intestine
Acesso em linha:http://link.springer.com/article/10.1186/s13036-019-0212-1
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