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A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells.

HNF4α has been implicated in IBD through a number of genome-wide association studies. Recently, we developed potent HNF4α agonists, including N-trans caffeoyltyramine (NCT). NCT was identified by structural similarity to previously the previously identified but weak HNF4α agonists alverine and benfl...

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Sonraí Bibleagrafaíochta
Main Authors: Seung-Hee Lee, Vimal Veeriah, Fred Levine
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science (PLoS) 2022-01-01
Sraith:PLoS ONE
Rochtain Ar Líne:https://doi.org/10.1371/journal.pone.0266066
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