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A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells.
HNF4α has been implicated in IBD through a number of genome-wide association studies. Recently, we developed potent HNF4α agonists, including N-trans caffeoyltyramine (NCT). NCT was identified by structural similarity to previously the previously identified but weak HNF4α agonists alverine and benfl...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science (PLoS)
2022-01-01
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| Collection: | PLoS ONE |
| Accès en ligne: | https://doi.org/10.1371/journal.pone.0266066 |
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