SOD1 in ALS: Taking Stock in Pathogenic Mechanisms and the Role of Glial and Muscle Cells

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still unclear, the discovery that familial cases of ALS are related to mutations in the Cu/Zn superoxide dismutase (SOD...

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Bibliografiska uppgifter
Huvudupphovsmän: Caterina Peggion, Valeria Scalcon, Maria Lina Massimino, Kelly Nies, Raffaele Lopreiato, Maria Pia Rigobello, Alessandro Bertoli
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI AG 2022-03-01
Serie:Antioxidants
Ämnen:
amyotrophic lateral sclerosis
SOD1
reactive oxygen species
ROS signaling
Ca<sup>2+</sup> homeostasis
transgenic mice
Länkar:https://www.mdpi.com/2076-3921/11/4/614
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