Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways

Shikonin, a botanical drug extracted from Lithospermum erythrorhizon, exhibits anti-cancer effects in various cancer cell lines. However, the mechanisms underlying these effects have not been completely elucidated yet. Here, we showed that Shikonin induces apoptosis and autophagy in A375 cells and i...

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Autors principals: Yongkang Liu, Xing Kang, Geng Niu, Senlin He, Tingting Zhang, Yuwei Bai, Yi Li, Houyan Hao, Chao Chen, Zhexing Shou, Bin Li
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis Group 2019-12-01
Col·lecció:Artificial Cells, Nanomedicine, and Biotechnology
Matèries:
Shikonin
apoptosis
autophagy
ROS
ER stress
p38
Accés en línia:https://www.tandfonline.com/doi/10.1080/21691401.2019.1575229
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