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(-)-Epigallocatechin-3-gallate protects against NO-induced ototoxicity through the regulation of caspase- 1, caspase-3, and NF-κB activation.

Excessive nitric oxide (NO) production is toxic to the cochlea and induces hearing loss. However, the mechanism through which NO induces ototoxicity has not been completely understood. The aim of this study was to gain further insight into the mechanism mediating NO-induced toxicity in auditory HEI-...

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Autores principales: Su-Jin Kim, Jeong-Han Lee, Beom-Su Kim, Hong-Seob So, Raekil Park, Noh-Yil Myung, Jae-Young Um, Seung-Heon Hong
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2012-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC3461011?pdf=render
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