Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer’s Disease

Amyloid-β (Aβ) accumulation and tauopathy are considered the pathological hallmarks of Alzheimer’s disease (AD), but attenuation in choline signaling, including decreased nicotinic acetylcholine receptors (nAChRs), is evident in the early phase of AD. Currently, there are no drugs that can suppress...

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Main Authors: Kazuyuki Takata, Hiroyuki Kimura, Daijiro Yanagisawa, Koki Harada, Kaneyasu Nishimura, Yoshihisa Kitamura, Shun Shimohama, Ikuo Tooyama
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2022-04-01
Serija:Molecules
Teme:
neurodegenerative disease
nicotinic acetylcholine receptors
glial cells
neuroprotection
neuroinflammation
subtype
Online dostop:https://www.mdpi.com/1420-3049/27/9/2780
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