Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer’s Disease

Amyloid-β (Aβ) accumulation and tauopathy are considered the pathological hallmarks of Alzheimer’s disease (AD), but attenuation in choline signaling, including decreased nicotinic acetylcholine receptors (nAChRs), is evident in the early phase of AD. Currently, there are no drugs that can suppress...

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Main Authors: Kazuyuki Takata, Hiroyuki Kimura, Daijiro Yanagisawa, Koki Harada, Kaneyasu Nishimura, Yoshihisa Kitamura, Shun Shimohama, Ikuo Tooyama
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2022-04-01
Series:Molecules
Assuntos:
neurodegenerative disease
nicotinic acetylcholine receptors
glial cells
neuroprotection
neuroinflammation
subtype
Acceso en liña:https://www.mdpi.com/1420-3049/27/9/2780
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