HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability

Abstract Background The integration of human papilloma virus (HPV) into host genome is one of the critical steps that lead to the progression of precancerous lesion into cancer. However, the mechanisms and consequences of such integration events are poorly understood. This study aims to explore thos...

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Hlavní autoři: Jun-Wei Zhao, Fang Fang, Yi Guo, Tai-Lin Zhu, Yun-Yun Yu, Fan-Fei Kong, Ling-Fei Han, Dong-Sheng Chen, Fang Li
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2016-11-01
Edice:Journal of Experimental & Clinical Cancer Research
Témata:
HPV16
Integration
Cervical oncogenesis
Chromosome instability
On-line přístup:http://link.springer.com/article/10.1186/s13046-016-0454-4
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