High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets.

BACKGROUND:Obesity has been associated with elevated plasma anandamide levels. In addition, anandamide has been shown to stimulate insulin secretion in vitro, suggesting that anandamide might be linked to hyperinsulinemia. OBJECTIVE:To determine whether high-fat diet-induced insulin resistance incre...

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Main Authors: Orison O Woolcott, Joyce M Richey, Morvarid Kabir, Robert H Chow, Malini S Iyer, Erlinda L Kirkman, Darko Stefanovski, Maya Lottati, Stella P Kim, L Nicole Harrison, Viorica Ionut, Dan Zheng, Isabel R Hsu, Karyn J Catalano, Jenny D Chiu, Heather Bradshaw, Qiang Wu, Cathryn M Kolka, Richard N Bergman
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4391925?pdf=render
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