Interference of retroviral envelope with vaccine-induced CD8+ T cell responses is relieved by co-administration of cytokine-encoding vectors

Abstract Background Retroviral envelope (Env) proteins are known to exhibit immunosuppressive properties, which become apparent not only in retroviral infections, but also in gene-based immunizations using retroviral immunogens, where envelope interferes with the induction of CD8+ T cell responses t...

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Main Authors: Nadine Bongard, Dennis Lapuente, Sonja Windmann, Ulf Dittmer, Matthias Tenbusch, Wibke Bayer
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2017-04-01
Series:Retrovirology
Assuntos:
Retrovirus
Envelope
Vaccine
Friend virus
Friend retrovirus
Immunosuppression
Acceso en liña:http://link.springer.com/article/10.1186/s12977-017-0352-7
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