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Increased Expression of Prolyl Endopeptidase Induced by Oxidative Stress in Nucleus Pulposus Cells Aggravates Intervertebral Disc Degeneration

A healthy microenvironment of the intervertebral disc tissue is characterized by hypoxia owing to its sparse vascular distribution. Oxidative stress plays a pivotal role in the pathological development of intervertebral disc degeneration (IVDD). We found that the expression of prolyl endopeptidase (...

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Main Authors: Huo-Liang Zheng, Wen-Ning Xu, Peng-Bo Chen, Lei-Sheng Jiang, Xin-Feng Zheng, Sheng-Dan Jiang
Formáid: Artigo
Teanga:Inglês
Foilsithe: Hindawi Limited 2022-01-01
Sraith:Oxidative Medicine and Cellular Longevity
Rochtain Ar Líne:http://dx.doi.org/10.1155/2022/9731800
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