Therapeutic potential of a novel prodrug of green tea extract in induction of apoptosis via ERK/JNK and Akt signaling pathway in human endometrial cancer

Abstract Background Previous studies have shown a major green tea polyphenol (−)-epigallocatechin-3-gallate ((−)-EGCG) as a powerful anti-cancer agent. However, its poor bioavailability and requirement of a high dosage to manifest activity have restricted its clinical application. Recently, our team...

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Main Authors: Gene Chi Wai Man, Jianzhang Wang, Yi Song, Jack Ho Wong, Yu Zhao, Tat San Lau, Kam Tong Leung, Tak Hang Chan, Huating Wang, Joseph Kwong, Tzi Bun Ng, Chi Chiu Wang
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2020-10-01
Series:BMC Cancer
Assuntos:
ProEGCG
Endometrial cancer
Apoptosis
Anticancer
Anti-angiogenesis
Akt pathway
Acceso en liña:http://link.springer.com/article/10.1186/s12885-020-07455-3
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