Interleukin-1 genetic polymorphisms in knee osteoarthritis: What do we know? A meta-analysis and systematic review

Purpose Interleukin-1 is the main proinflammatory cytokine in osteoarthritis (OA). Several single-nucleotide polymorphisms (SNPs) within the IL-1 gene cluster (IL-1β, IL-1R1, and IL-1RN) have been determined, but their associations with knee OA remain poorly understood. The present study aimed to id...

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Main Authors: Nicolaas C Budhiparama MD, PhD, Imelda Lumban-Gaol MD, Herawati Sudoyo MD, PhD, Rahadyan Magetsari MD, PhD, Tri Wibawa MD, PhD
Format: Artigo
Language:Inglês
Published: SAGE Publishing 2022-01-01
Series:Journal of Orthopaedic Surgery
Online Access:https://doi.org/10.1177/23094990221076652
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