Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study

Background: The present study evaluated the safety, pharmacokinetics/pharmacodynamics (PK/PD), and absolute bioavailability (Fabs) of Dex nasal spray in healthy adult subjects, which serves as a bridge for the subsequent study in children.Methods: Part 1: a double-blind, placebo-controlled, single a...

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Detalhes bibliográficos
Main Authors: Yun Kuang, Sai-Ying Wang, Meng-Na Wang, Guo-Ping Yang, Can Guo, Shuang Yang, Xing-Fei Zhang, Xiao-Yan Yang, Qi Pei, Chan Zou, Yan-Hong He, Ying-Yong Zhou, Kai-Ming Duan, Jie Huang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Pharmacology
Assuntos:
dexmedetomidine nasal spray
pharmacokinetics
pharmacodynamics
absolute bioavailability
healthy subjects
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.871492/full
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