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Optimization of IL-1RA structure to achieve a smaller protein with a higher affinity to its receptor
Abstract Interleukine-1 family cytokines are key orchestrators of innate and adaptive immunity. In particular, up-regulation of IL-1R1 via its agonistic ligands consisting of IL-1β and IL-1α is implicated in a variety of human diseases, such as rheumatoid arthritis, psoriasis, type I diabetes, amyot...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2022-05-01
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| Colecção: | Scientific Reports |
| Acesso em linha: | https://doi.org/10.1038/s41598-022-11100-3 |
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