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Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now?

Cells expressing IDO suppress innate and adaptive immunity to promote tolerance by catabolizing the amino acid tryptophan (Trp) and other indole compounds. Interferon type I (IFN-I) and type II (IFN-II) produced at sites of inflammation or by activated immune cells are potent IDO inducers because ma...

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Bibliographische Detailangaben
Hauptverfasser: Andrew L. Mellor, Henrique Lemos, Lei Huang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017-10-01
Schriftenreihe:Frontiers in Immunology
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Online Zugang:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01360/full
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