Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway

Abstract Background T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods In this study, we collected the bon...

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Detalhes bibliográficos
Main Authors: Yanfei Jia, Yan Qi, Yunshan Wang, Xiaoli Ma, Yihui Xu, Jun Wang, Xiaoqian Zhang, Meihua Gao, Beibei Cong, Shuyi Han
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-01-01
Colecção:Cancer Cell International
Assuntos:
CD59
T-acute lymphoblastic leukemia
Apoptosis
AKT
Notch1
Acesso em linha:http://link.springer.com/article/10.1186/s12935-018-0714-9
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