DEVELOPMENT, IN-VITRO AND EX-VIVO EVALUATION OF MUCO-ADHESIVE BUCCAL TABLETS OF HYDRALAZINE HYDROCHLORIDE

Abstract Hydralazine hydrochloride is an anti-hypertensive drug. The drug has poor oral bioavailability (BA) of about 30- 50% due to extensive first-pass metabolism. Hence, the buccal delivery was used to enhance the BA of hydralazine hydrochloride. Buccal muco-adhesive tablets were prepared by dire...

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Main Authors: Kumara Swamy Samanthula, Mahendra Kumar CB, Agaiah Goud Bairi, Shobha Rani Satla
Formato: Artigo
Idioma:Inglês
Publicado em: Universidade de São Paulo 2022-04-01
Colecção:Brazilian Journal of Pharmaceutical Sciences
Assuntos:
Hydralazine hydrochloride. First-pass metabolism. Buccal muco-adhesive tablets. In- vitro
ex-vivo
Acesso em linha:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100547&tlng=en
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