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Adrenomedullin Deficiency and Aging Exacerbate Ischemic White Matter Injury after Prolonged Cerebral Hypoperfusion in Mice

Adrenomedullin was originally isolated from pheochromocytoma cells and reduces insulin resistance by decreasing oxidative stress. White matter lesions induced by aging and hyperglycemia play a crucial role in cognitive impairment in poststroke patients. Here, we examine whether adrenomedullin defici...

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Detalhes bibliográficos
Main Authors: Yumiko Mitome-Mishima, Nobukazu Miyamoto, Ryota Tanaka, Tatsuo Shimosawa, Hidenori Oishi, Hajime Arai, Nobutaka Hattori, Takao Urabe
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Limited 2014-01-01
Colecção:BioMed Research International
Acesso em linha:http://dx.doi.org/10.1155/2014/861632
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