rAAV8 and rAAV9-Mediated Long-Term Muscle Transduction with Tacrolimus (FK506) in Non-Human Primates

To establish an efficient, safe immunosuppressive regimen of adeno-associated vector (AAV)-mediated gene therapy for Duchenne muscular dystrophy (DMD), we evaluated the effect of tacrolimus (FK506) on skeletal muscle transduction with AAV8 and AAV9 vectors expressing the LacZ and microdystrophin (M3...

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Main Authors: Akiko Ishii, Hironori Okada, Hiromi Hayashita-Kinoh, Jin-Hong Shin, Akira Tamaoka, Takashi Okada, Shin’ichi Takeda
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Assuntos:
tacrolimus
muscular dystrophy
recombinant adeno-associated virus
gene therapy
microdystrophin
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2329050120300991
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