Association of the CYP2B6 gene with anti-tuberculosis drug-induced hepatotoxicity in a Brazilian Amazon population

Objectives: The treatment of tuberculosis (TB) remains a challenge owing to the high incidence of drug-induced hepatotoxicity. The aim of this study was to examine the effect of two gene polymorphisms, one in the CYP2B6 (rs3745274) gene and one in the CYP3A5 (rs776746) gene, on the development of he...

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Main Authors: Débora Christina Ricardo Oliveira Fernandes, Ney Pereira Carneiro Santos, Milene Raiol Moraes, Ana Cristina Oliveira Braga, Cleonardo Augusto Silva, Andrea Ribeiro-dos-Santos, Sidney Santos
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015-04-01
Serier:International Journal of Infectious Diseases
Fag:
Tuberculosis
Hepatotoxicity
CYP2B6
CYP3A5
Online adgang:http://www.sciencedirect.com/science/article/pii/S1201971214015070
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