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Leucine Carboxyl Methyltransferase Downregulation and Protein Phosphatase Methylesterase Upregulation Contribute Toward the Inhibition of Protein Phosphatase 2A by α-Synuclein

The pathology of Parkinson’s disease (PD) is characterized by intracellular neurofibrillary tangles of phosphorylated α-synuclein (α-syn). Protein phosphatase 2A (PP2A) is responsible for α-syn dephosphorylation. Previous work has demonstrated that α-syn can regulate PP2A activity. However, the mech...

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Bibliografiske detaljer
Main Authors: Hao Tian, Yongquan Lu, Jia Liu, Weijin Liu, Lingling Lu, Chunli Duan, Ge Gao, Hui Yang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-06-01
Serier:Frontiers in Aging Neuroscience
Fag:
Online adgang:https://www.frontiersin.org/article/10.3389/fnagi.2018.00173/full
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