Leucine Carboxyl Methyltransferase Downregulation and Protein Phosphatase Methylesterase Upregulation Contribute Toward the Inhibition of Protein Phosphatase 2A by α-Synuclein

The pathology of Parkinson’s disease (PD) is characterized by intracellular neurofibrillary tangles of phosphorylated α-synuclein (α-syn). Protein phosphatase 2A (PP2A) is responsible for α-syn dephosphorylation. Previous work has demonstrated that α-syn can regulate PP2A activity. However, the mech...

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Hlavní autoři: Hao Tian, Yongquan Lu, Jia Liu, Weijin Liu, Lingling Lu, Chunli Duan, Ge Gao, Hui Yang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018-06-01
Edice:Frontiers in Aging Neuroscience
Témata:
Parkinson’s disease
α-synuclein phosphorylation
PP2A methylation
LCMT-1
PME-1
PP2A regulatory subunits
On-line přístup:https://www.frontiersin.org/article/10.3389/fnagi.2018.00173/full
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