Identification of Novel Microsatellite Markers Flanking the SMN1 and SMN2 Duplicated Region and Inclusion Into a Single-Tube Tridecaplex Panel for Haplotype-Based Preimplantation Genetic Testing of Spinal Muscular Atrophy

Preimplantation genetic testing for the monogenic disorder (PGT-M) spinal muscular atrophy (SMA) is significantly improved by supplementation of SMN1 deletion detection with marker-based linkage analysis. To expand the availability of informative markers for PGT-M of SMA, we identified novel non-dup...

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Main Authors: Mingjue Zhao, Mulias Lian, Felicia S.H. Cheah, Arnold S.C. Tan, Anupriya Agarwal, Samuel S. Chong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-11-01
Colecção:Frontiers in Genetics
Assuntos:
microsatellite
preimplantation genetic testing for monogenic disorders (PGT-M)
spinal muscular atrophy (SMA)
spinal motor neuron (SMN)
multiplex PCR
haplotype
Acesso em linha:https://www.frontiersin.org/article/10.3389/fgene.2019.01105/full
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