Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study

Process intensification has shown great potential to increase productivity and reduce costs in biomanufacturing. This case study describes the evolution of a manufacturing process from a conventional processing scheme at 1000-L scale (Process A, n = 5) to intensified processing schemes at both 1000-...

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Bibliographic Details
Main Authors: Jianlin Xu, Xuankuo Xu, Chao Huang, James Angelo, Christopher L. Oliveira, Mengmeng Xu, Xia Xu, Deniz Temel, Julia Ding, Sanchayita Ghose, Michael C. Borys, Zheng Jian Li
Format: Artigo
Language:Inglês
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Process intensification
N-1 perfusion
multi-column chromatography
integrated pool-less polishing
cost of goods
biomanufacturing
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1770669
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