Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons

The muscarinic acetylcholine type 1 receptor (M1R) is a metabotropic G protein-coupled receptor. Knockout of M1R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse models of peripheral neuropathy. We tested the...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Mohammad G. Sabbir, Nigel A. Calcutt, Paul Fernyhough
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2018-06-01
Серии:Frontiers in Neuroscience
Предметы:
muscarinic receptors
mitochondria
antagonist
G proteins
cytoskeleton dynamics
mitochondrial trafficking
Online-ссылка:https://www.frontiersin.org/article/10.3389/fnins.2018.00402/full
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы