Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons

The muscarinic acetylcholine type 1 receptor (M1R) is a metabotropic G protein-coupled receptor. Knockout of M1R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse models of peripheral neuropathy. We tested the...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Mohammad G. Sabbir, Nigel A. Calcutt, Paul Fernyhough
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018-06-01
Serie:Frontiers in Neuroscience
Soggetti:
muscarinic receptors
mitochondria
antagonist
G proteins
cytoskeleton dynamics
mitochondrial trafficking
Accesso online:https://www.frontiersin.org/article/10.3389/fnins.2018.00402/full
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi