Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons

The muscarinic acetylcholine type 1 receptor (M1R) is a metabotropic G protein-coupled receptor. Knockout of M1R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse models of peripheral neuropathy. We tested the...

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Main Authors: Mohammad G. Sabbir, Nigel A. Calcutt, Paul Fernyhough
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-06-01
Serier:Frontiers in Neuroscience
Fag:
muscarinic receptors
mitochondria
antagonist
G proteins
cytoskeleton dynamics
mitochondrial trafficking
Online adgang:https://www.frontiersin.org/article/10.3389/fnins.2018.00402/full
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