Exercise and insulin resistance in PCOS: muscle insulin signalling and fibrosis

Objective: Mechanisms of insulin resistance in polycystic ovary syndrome (PCOS) remain ill defined, contributing to sub-optimal therapies. Recognising skeletal muscle plays a key role in glucose homeostasis we investigated early insulin signalling, its association with aberrant transforming growth f...

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Detalhes bibliográficos
Main Authors: N K Stepto, D Hiam, M Gibson-Helm, S Cassar, C L Harrison, S K Hutchison, A E Joham, B J Canny, A Moreno-Asso, B J Strauss, N Hatzirodos, R J Rodgers, H J Teede
Formato: Artigo
Idioma:Inglês
Publicado em: Bioscientifica 2020-04-01
Colecção:Endocrine Connections
Assuntos:
mechanistic target of rapamysin (mtor)
typical and atypical protein kinase c
transforming growth factor β receptor 2 (tgfbrii)
collagen
treadmill exercise training
high intensity interval training
hyperandrogenism
Acesso em linha:https://ec.bioscientifica.com/view/journals/ec/9/4/EC-19-0551.xml
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