Humanized CD19 CAR-T cells in relapsed/refractory B-ALL patients who relapsed after or failed murine CD19 CAR-T therapy

Abstract Background For CD19-positive relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL) after treatment with murine CD19 (mCD19) CAR-T, the reinfusion of mCD19 CAR-T cells may be ineffective due to anti-mouse single-chain variable fragment (scFv) antibody caused by mCD19 CAR. To ov...

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Hauptverfasser: Lihong An, Yuehui Lin, Biping Deng, Zhichao Yin, Defeng Zhao, Zhuojun Ling, Tong Wu, Yongqiang Zhao, Alex H. Chang, Chunrong Tong, Shuangyou Liu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2022-04-01
Schriftenreihe:BMC Cancer
Schlagworte:
Chimeric antigen receptor-T
Acute lymphoblastic leukemia
Relapsed/refractory
Single-chain variable fragment
Online Zugang:https://doi.org/10.1186/s12885-022-09489-1
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