Tumor-targeting Salmonella typhimurium A1-R suppressed an imatinib-resistant gastrointestinal stromal tumor with c-kit exon 11 and 17 mutations

Gastrointestinal stromal tumor (GIST) is a refractory disease in need of novel efficacious therapy. The aim of our study was to evaluate the effectiveness of tumor-targeting Salmonella typhimurium A1-R (S. typhimurium A1-R) using on a patient derived orthotopic xenograft (PDOX) model of imatinib-res...

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Detalles Bibliográficos
Main Authors: Kentaro Miyake, Kei Kawaguchi, Masuyo Miyake, Ming Zhao, Tasuku Kiyuna, Kentaro Igarashi, Zhiying Zhang, Takashi Murakami, Yunfeng Li, Scott D. Nelson, Michael Bouvet, Irmina Elliott, Tara A. Russell, Arun S. Singh, Yukihiko Hiroshima, Masashi Momiyama, Ryusei Matsuyama, Takashi Chishima, Shree Ram Singh, Itaru Endo, Fritz C. Eilber, Robert M. Hoffman
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2018-06-01
Series:Heliyon
Assuntos:
Biochemistry
Cancer research
Genetics
Microbiology
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2405844018303414
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