Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation.

Although chronic hepatitis C virus (HCV) infection has been treated with the combination of interferon alpha (IFN-α) and ribavirin (RBV) for over a decade, the mechanism of antiviral synergy is not well understood. We aimed to determine the synergistic antiviral mechanisms of IFN-α and RBV combinati...

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Hauptverfasser: Rajesh Panigrahi, Sidhartha Hazari, Sruti Chandra, Partha K Chandra, Sibnarayan Datta, Ramazan Kurt, Craig E Cameron, Zhuhui Huang, Haitao Zhang, Robert F Garry, Luis A Balart, Srikanta Dash
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science (PLoS) 2013-01-01
Schriftenreihe:PLoS ONE
Online Zugang:http://europepmc.org/articles/PMC3751885?pdf=render
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