Chelerythrine Attenuates Renal Ischemia/Reperfusion-induced Myocardial Injury by Activating CSE/H2S via PKC/NF-κB Pathway in Diabetic Rats

Background/Aims: Chelerythrine (CHE), a benzophenanthridine alkaloid, is a potent, selective, and cell-permeable protein kinase C (PKC) inhibitor. The purpose of the present study was to evaluate the effect of CHE on myocardial recovery after renal ischemia/reperfusion (I/R)-induced myocardial injur...

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Détails bibliographiques
Auteurs principaux: Bo Hu, Guangtao Xu, Yongxia Zheng, Fei Tong, Ping Qian, Xiaoyan Pan, Xinmei Zhou, Ruilin Shen
Format: Artigo
Langue:Inglês
Publié: Karger Publishers 2017-06-01
Collection:Kidney & Blood Pressure Research
Sujets:
Chelerythrine
Ischemia/reperfusion
Diabetes mellitus
Cystathionine-γ-lyase
Hydrogen disulfide
Protein kinase C
Nuclear factor-κ B
Accès en ligne:http://www.karger.com/Article/FullText/477948
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