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Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil.

New promising avenues for the pharmacological treatment of skeletal and heart muscle diseases rely on direct sarcomeric modulators, which are molecules that can directly bind to sarcomeric proteins and either inhibit or enhance their activity. A recent breakthrough has been the discovery of the myos...

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Bibliografski detalji
Glavni autori: Shaima Hashem, Matteo Tiberti, Arianna Fornili
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2017-11-01
Serija:PLoS Computational Biology
Online pristup:http://europepmc.org/articles/PMC5690683?pdf=render
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